5/29/2025
Last update
5/29/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Moderately Good
Based on 18 Reviews
7.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
1,360 mcg DFE** (800 mcg folic acid)
340%
Vitamin B-12 (as Cyanocobalamin)
25 mcg
1042%
Top Medical Research Studies
8
We aimed to understand how folic acid affects bone cancer pain, a challenging condition that isn't easily managed with typical treatments. In our study, we induced bone cancer pain in rats by injecting Walker 256 tumor cells into their tibia. To assess pain response, we measured how quickly they withdrew their paws in response to pressure and heat.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
Read More
8
Folic acid supports bone health
We undertook a study to investigate the effects of different doses of folic acid on bone health during pregnancy, particularly focusing on bone resorption markers associated with osteoporosis. In this randomized, double-blind trial, forty-five pregnant women participated, with some taking a high dose of 5 mg per day and others taking a lower dose of 0.5 mg per day throughout their pregnancy.
Our findings indicated that higher doses of folic acid appeared to help lower important markers of bone resorption, namely soluble Receptor Activator of Nuclear Factor-Kappa B ligand (sRANKL) and Tumor Necrosis Factor alpha (TNFα), while increasing Osteoprotegerin (OPG). This balance may contribute to improved bone health, potentially reducing the risk of Pregnancy Associated Osteoporosis (PAO) in affected women.
While the study did not directly measure bone pain outcomes, the biochemical changes observed suggest an encouraging approach to support bone health and prevent complications that can lead to pain and fractures. Overall, we believe that higher folic acid doses during pregnancy may offer beneficial effects on bone metabolism, thus contributing positively to women’s health in this crucial period.
Our findings indicated that higher doses of folic acid appeared to help lower important markers of bone resorption, namely soluble Receptor Activator of Nuclear Factor-Kappa B ligand (sRANKL) and Tumor Necrosis Factor alpha (TNFα), while increasing Osteoprotegerin (OPG). This balance may contribute to improved bone health, potentially reducing the risk of Pregnancy Associated Osteoporosis (PAO) in affected women.
While the study did not directly measure bone pain outcomes, the biochemical changes observed suggest an encouraging approach to support bone health and prevent complications that can lead to pain and fractures. Overall, we believe that higher folic acid doses during pregnancy may offer beneficial effects on bone metabolism, thus contributing positively to women’s health in this crucial period.
Read More
7
We investigated how carnitine and folic acid supplementation could mitigate bone pain and fatigue in patients with beta-thalassemia minor. The study involved 73 participants, who received specific supplement combinations over three months.
Our findings showed that carnitine significantly improved plasma levels and reduced bone pain. Although folic acid alone increased red blood cell folate levels, it did not provide significant relief from bone pain or muscle weakness as carnitine did.
Overall, carnitine seems effective in reducing bone pain complaints for individuals with beta-thalassemia minor.
Our findings showed that carnitine significantly improved plasma levels and reduced bone pain. Although folic acid alone increased red blood cell folate levels, it did not provide significant relief from bone pain or muscle weakness as carnitine did.
Overall, carnitine seems effective in reducing bone pain complaints for individuals with beta-thalassemia minor.
Read More
Most Useful Reviews
9
Menstrual relief
16 people found this helpful
This folic acid helped me regulate a cycle plagued by 2-3 month delays. Just two weeks into taking it, my cycle resumed normally, which astonished me! I had tried various remedies before with minimal success. Although hormones could regulate it, I preferred not to take them. Consuming one tablet daily as instructed worked wonders. I recommend this to all women! It alleviates pain and normalises the female system perfectly.
Read More
9
Pain relief
2 people found this helpful
This product truly works. It's excellent for easing menopausal hot flashes and assists thyroid function. For period pain, I would take two pills at the onset, and within ten minutes the pain eased; if there were any lingering cramps, I’d repeat the dose and, like magic, the discomfort vanished. It's uplifting for energy levels, especially if you suffer from ME/CFS or chronic fatigue. I appreciate that it contains B12 as well. Highly satisfied!
Read More
9
Pain alleviated
1 people found this helpful
I've used this for sickle-cell anaemia, and the pain and fatigue have vanished, which is simply wonderful!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
- All Researches
8
We aimed to understand how folic acid affects bone cancer pain, a challenging condition that isn't easily managed with typical treatments. In our study, we induced bone cancer pain in rats by injecting Walker 256 tumor cells into their tibia. To assess pain response, we measured how quickly they withdrew their paws in response to pressure and heat.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
Read More
8
Folic acid supports bone health
We undertook a study to investigate the effects of different doses of folic acid on bone health during pregnancy, particularly focusing on bone resorption markers associated with osteoporosis. In this randomized, double-blind trial, forty-five pregnant women participated, with some taking a high dose of 5 mg per day and others taking a lower dose of 0.5 mg per day throughout their pregnancy.
Our findings indicated that higher doses of folic acid appeared to help lower important markers of bone resorption, namely soluble Receptor Activator of Nuclear Factor-Kappa B ligand (sRANKL) and Tumor Necrosis Factor alpha (TNFα), while increasing Osteoprotegerin (OPG). This balance may contribute to improved bone health, potentially reducing the risk of Pregnancy Associated Osteoporosis (PAO) in affected women.
While the study did not directly measure bone pain outcomes, the biochemical changes observed suggest an encouraging approach to support bone health and prevent complications that can lead to pain and fractures. Overall, we believe that higher folic acid doses during pregnancy may offer beneficial effects on bone metabolism, thus contributing positively to women’s health in this crucial period.
Our findings indicated that higher doses of folic acid appeared to help lower important markers of bone resorption, namely soluble Receptor Activator of Nuclear Factor-Kappa B ligand (sRANKL) and Tumor Necrosis Factor alpha (TNFα), while increasing Osteoprotegerin (OPG). This balance may contribute to improved bone health, potentially reducing the risk of Pregnancy Associated Osteoporosis (PAO) in affected women.
While the study did not directly measure bone pain outcomes, the biochemical changes observed suggest an encouraging approach to support bone health and prevent complications that can lead to pain and fractures. Overall, we believe that higher folic acid doses during pregnancy may offer beneficial effects on bone metabolism, thus contributing positively to women’s health in this crucial period.
Read More
7
We investigated how carnitine and folic acid supplementation could mitigate bone pain and fatigue in patients with beta-thalassemia minor. The study involved 73 participants, who received specific supplement combinations over three months.
Our findings showed that carnitine significantly improved plasma levels and reduced bone pain. Although folic acid alone increased red blood cell folate levels, it did not provide significant relief from bone pain or muscle weakness as carnitine did.
Overall, carnitine seems effective in reducing bone pain complaints for individuals with beta-thalassemia minor.
Our findings showed that carnitine significantly improved plasma levels and reduced bone pain. Although folic acid alone increased red blood cell folate levels, it did not provide significant relief from bone pain or muscle weakness as carnitine did.
Overall, carnitine seems effective in reducing bone pain complaints for individuals with beta-thalassemia minor.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 18 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Menstrual relief
16 people found this helpful
This folic acid helped me regulate a cycle plagued by 2-3 month delays. Just two weeks into taking it, my cycle resumed normally, which astonished me! I had tried various remedies before with minimal success. Although hormones could regulate it, I preferred not to take them. Consuming one tablet daily as instructed worked wonders. I recommend this to all women! It alleviates pain and normalises the female system perfectly.
Read More
9
Pain relief
2 people found this helpful
This product truly works. It's excellent for easing menopausal hot flashes and assists thyroid function. For period pain, I would take two pills at the onset, and within ten minutes the pain eased; if there were any lingering cramps, I’d repeat the dose and, like magic, the discomfort vanished. It's uplifting for energy levels, especially if you suffer from ME/CFS or chronic fatigue. I appreciate that it contains B12 as well. Highly satisfied!
Read More
9
Pain alleviated
1 people found this helpful
I've used this for sickle-cell anaemia, and the pain and fatigue have vanished, which is simply wonderful!
Read More
9
Pain relief noted
1 people found this helpful
Folic acid from Now Foods is an excellent remedy for women. It has stabilised my cycle, and the pain during menstruation has vanished. I've already taken three packs, and I am satisfied with everything.
Read More
6
Multiple benefits
98 people found this helpful
The ingredients are high quality, the size is good, and it’s very effective for folic acid deficiency. It has boosted my energy unusually, benefitting my joints, bones, muscles, skin, and hair. It has improved my sleep and immune system, with no unpleasant taste. Perfect for all ages and excellently packaged. I loved it and it worked wonderfully for me; thank you, iHerb.
Read More
Frequently Asked Questions
9
Menstrual relief
16 people found this helpful
This folic acid helped me regulate a cycle plagued by 2-3 month delays. Just two weeks into taking it, my cycle resumed normally, which astonished me! I had tried various remedies before with minimal success. Although hormones could regulate it, I preferred not to take them. Consuming one tablet daily as instructed worked wonders. I recommend this to all women! It alleviates pain and normalises the female system perfectly.
9
Strength improved
3 people found this helpful
I take one tablet daily for a month as a preventative measure. I feel calmer, and my PMS pain and overall fatigue have reduced significantly. The combination of folic acid and vitamin B12 works well. It’s beneficial that I can share the tablets with my mother and a friend. Just a note: for those pregnant or planning pregnancy, I believe one tablet per day might not suffice; thus, consultation with a doctor is necessary. All health!
9
No more pain
2 people found this helpful
I consumed this for about a month and a half, during which my body was rejuvenated and cycles returned like clockwork, with no pain or PMS. Irritability and fatigue have vanished. My nails and hair have grown faster and strengthened, and my skin has cleared up. In a word, beauty.
5
Gradual improvement
1 people found this helpful
I experience pain after herpes zoster, so I am currently taking this alongside vitamin B12 as my pharmacist suggested. The pain doesn’t completely disappear, but I understand it is improving gradually.
9
Pain relief
2 people found this helpful
This product truly works. It's excellent for easing menopausal hot flashes and assists thyroid function. For period pain, I would take two pills at the onset, and within ten minutes the pain eased; if there were any lingering cramps, I’d repeat the dose and, like magic, the discomfort vanished. It's uplifting for energy levels, especially if you suffer from ME/CFS or chronic fatigue. I appreciate that it contains B12 as well. Highly satisfied!
6
Multiple benefits
98 people found this helpful
The ingredients are high quality, the size is good, and it’s very effective for folic acid deficiency. It has boosted my energy unusually, benefitting my joints, bones, muscles, skin, and hair. It has improved my sleep and immune system, with no unpleasant taste. Perfect for all ages and excellently packaged. I loved it and it worked wonderfully for me; thank you, iHerb.
6
Improved health
Folic acid helps me improve my blood and bone health and positively impacts cases of anaemia and iron deficiency.
7.5
Bone decay aid
This vitamin provides good quality and effective support for individuals suffering from bone decay and anaemia.
7
We investigated how carnitine and folic acid supplementation could mitigate bone pain and fatigue in patients with beta-thalassemia minor. The study involved 73 participants, who received specific supplement combinations over three months.
Our findings showed that carnitine significantly improved plasma levels and reduced bone pain. Although folic acid alone increased red blood cell folate levels, it did not provide significant relief from bone pain or muscle weakness as carnitine did.
Overall, carnitine seems effective in reducing bone pain complaints for individuals with beta-thalassemia minor.
Our findings showed that carnitine significantly improved plasma levels and reduced bone pain. Although folic acid alone increased red blood cell folate levels, it did not provide significant relief from bone pain or muscle weakness as carnitine did.
Overall, carnitine seems effective in reducing bone pain complaints for individuals with beta-thalassemia minor.
8
We aimed to understand how folic acid affects bone cancer pain, a challenging condition that isn't easily managed with typical treatments. In our study, we induced bone cancer pain in rats by injecting Walker 256 tumor cells into their tibia. To assess pain response, we measured how quickly they withdrew their paws in response to pressure and heat.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
8
Folic acid supports bone health
We undertook a study to investigate the effects of different doses of folic acid on bone health during pregnancy, particularly focusing on bone resorption markers associated with osteoporosis. In this randomized, double-blind trial, forty-five pregnant women participated, with some taking a high dose of 5 mg per day and others taking a lower dose of 0.5 mg per day throughout their pregnancy.
Our findings indicated that higher doses of folic acid appeared to help lower important markers of bone resorption, namely soluble Receptor Activator of Nuclear Factor-Kappa B ligand (sRANKL) and Tumor Necrosis Factor alpha (TNFα), while increasing Osteoprotegerin (OPG). This balance may contribute to improved bone health, potentially reducing the risk of Pregnancy Associated Osteoporosis (PAO) in affected women.
While the study did not directly measure bone pain outcomes, the biochemical changes observed suggest an encouraging approach to support bone health and prevent complications that can lead to pain and fractures. Overall, we believe that higher folic acid doses during pregnancy may offer beneficial effects on bone metabolism, thus contributing positively to women’s health in this crucial period.
Our findings indicated that higher doses of folic acid appeared to help lower important markers of bone resorption, namely soluble Receptor Activator of Nuclear Factor-Kappa B ligand (sRANKL) and Tumor Necrosis Factor alpha (TNFα), while increasing Osteoprotegerin (OPG). This balance may contribute to improved bone health, potentially reducing the risk of Pregnancy Associated Osteoporosis (PAO) in affected women.
While the study did not directly measure bone pain outcomes, the biochemical changes observed suggest an encouraging approach to support bone health and prevent complications that can lead to pain and fractures. Overall, we believe that higher folic acid doses during pregnancy may offer beneficial effects on bone metabolism, thus contributing positively to women’s health in this crucial period.
References
- Tabei SM, Mazloom M, Shahriari M, Zareifar S, Azimi A, et al. Determining and surveying the role of carnitine and folic acid to decrease fatigue in β-thalassemia minor subjects. Pediatr Hematol Oncol. 2013;30:742. 10.3109/08880018.2013.771388
- Gu YJ, Qian HY, Zhou F, Zhang L, Chen L, et al. Folic acid relieves bone cancer pain by downregulating P2X2/3 receptors in rats. Brain Res. 2023;1811:148405. 10.1016/j.brainres.2023.148405
- Fathi Maroufi N, Ghorbanihaghjo A, Sayyah Melli M, Vaezi M, Hekmati Azar Mehrabani Z, et al. Effects of High and Low Doses of Folic Acid on the Soluble Receptor Activator of Nuclear Factor-kappa B Ligand/Osteoprotegerin Ratio during Pregnancy. Iran J Public Health. 2017;46:517.
